Unraveling the role of host endocytic proteins in pedestal formation during enteropathogenic Escherichia coli infection.
نویسندگان
چکیده
Charles Darkoh1,2 and Herbert L. DuPont1,2,3,4,5 1Graduate School of Biomedical Sciences, Molecular Pathology Program, The University of Texas; 2The University of Texas School of Public Health, Center for Infectious Diseases; 3Department of Internal Medicine, The University of Texas Medical School; 4Internal Medicine Service, St. Luke's Episcopal Hospital; and 5Department of Medicine, Baylor College of Medicine, Houston, Texas
منابع مشابه
Role for CD2AP and other endocytosis-associated proteins in enteropathogenic Escherichia coli pedestal formation.
Enteropathogenic Escherichia coli (EPEC) strains are extracellular pathogens that generate actin-rich structures (pedestals) beneath the adherent bacteria as part of their virulence strategy. Pedestals are hallmarks of EPEC infections, and their efficient formation in vitro routinely requires phosphorylation of the EPEC effector protein Tir at tyrosine 474 (Y474). This phosphorylation results i...
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Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) are closely related pathogens. During infection, EPEC and EHEC use a type III secretion system (TTSS) to translocate effector proteins into the infected cells and thereby modify specific host functions. These include transient filopodium formation which is Cdc42-dependent. Filopodia formation is followed by assembly ...
متن کاملTir Is Essential for the Recruitment of Tks5 to Enteropathogenic Escherichia coli Pedestals
Enteropathogenic Escherichia coli (EPEC) is a bacterial pathogen that infects the epithelial lining of the small intestine and causes diarrhea. Upon attachment to the intestinal epithelium, EPEC uses a Type III Secretion System to inject its own high affinity receptor Translocated intimin receptor (Tir) into the host cell. Tir facilitates tight adhesion and recruitment of actin-regulating prote...
متن کاملRecruitment of cytoskeletal and signaling proteins to enteropathogenic and enterohemorrhagic Escherichia coli pedestals.
Enteropathogenic Escherichia coli (EPEC) is a human pathogen that attaches to intestinal epithelial cells and causes chronic watery diarrhea. A close relative, enterohemorrhagic E. coli (EHEC), causes severe bloody diarrhea and hemolytic-uremic syndrome. Both pathogens insert a protein, Tir, into the host cell plasma membrane where it binds intimin, the outer membrane ligand of EPEC and EHEC. T...
متن کاملAmino acid residues within enterohemorrhagic Escherichia coli O157:H7 Tir involved in phosphorylation, alpha-actinin recruitment, and Nck-independent pedestal formation.
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 and enteropathogenic E. coli (EPEC) adherence to epithelial cells results in the formation of actin pedestals. Pedestal formation requires the bacterial protein Tir, which is inserted into the epithelial cell plasma membrane by the type III secretion system. EPEC and EHEC use different Tir-based mechanisms for pedestal formation, and the EPEC Ti...
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عنوان ژورنال:
- The Journal of infectious diseases
دوره 204 5 شماره
صفحات -
تاریخ انتشار 2011